In this sweeping regional history, anthropologist Robbie Ethridge traces the metamorphosis of the Native South from first contact in 1540 to the dawn of the eighteenth century, when indigenous people no longer lived in a purely Indian world but rather on the edge of an expanding European empire. Using a framework that Ethridge calls the “Mississippian shatter zone” to explicate these tumultuous times, From Chicaza to Chickasaw examines the European invasion, the collapse of the precontact Mississippian world, and the restructuring of discrete chiefdoms into coalescent Native societies in a colonial world. The story of one group — the Chickasaws — is closely followed through this period.