This book constitutes the revised selected papers of the 10th International Conference on Cloud Computing, Big Data & Emerging Topics, JCC-BD&ET 2022, held in La Plata, Argentina*, in June-July 2022. The 9 full papers were carefully reviewed and selected from a total of 23 submissions.  The papers are organized in topical sections on: Parallel and Distributed Computing; Machine and Deep Learning;  Cloud and High-Performance Computing, Machine and Deep Learning, and Virtual Reality.