GenAI has rapidly and universally disrupted teaching, learning, and assessing with integrity. In this Element, the authors first orient readers to the academic integrity landscape and then examine historical technological disruptions to academic integrity for lessons learned. Readers are then transported to 2045 with a fictional depiction of the type of university that will unfortunately emerge if we continue our historical practice of layering technology onto a 20th century educational platform rather than reenvisioning academic integrity. After analyzing this possible future, the authors offer a multi-layered and balanced approach to the problem through developing guidelines, policies and procedures, rethinking assessment design, and cultivating humans who will act ethically, in the age of AI. Overall, this Element offers evidence-based strategies that instructors and institutions can adapt to their contexts, emphasizing that as humans, we have the agency to shape the integrity we want and deserve.